NEURALGIA SUPPORT BLEND 30ML

NEURALGIA SUPPORT BLEND 30ML

Apply a small amount to intact skin over or surrounding the affected area and massage gently.

Do not aggressively massage directly over a severely painful or hypersensitive nerve.

For touch-sensitive areas, a thin gentle application may be better tolerated.

NEURALGIA SUPPORT BLEND 30ML

Avoid:

Eyes
Face
Mucous membranes
Open wounds
Broken skin
Severely inflamed skin

Wash hands after application.

Patch test before first use.

Peppermint produces cooling and Clove may produce warming or irritation in sensitive skin.

Discontinue if significant burning, redness or worsening nerve pain occurs.

NEURALGIA SUPPORT BLEND 30ML

Frankincense

Peppermint

Lavender

Copaiba

St John’s Wort

Helichrysum italicum

German Chamomile

Black Spruce

Ginger

Sweet Marjoram

Cedarwood

Clove

Olive Oil

NEURALGIA SUPPORT BLEND 30ML

Neuralgia Support is a concentrated medicinal botanical formulation developed specifically around the biological mechanisms involved in nerve-associated pain.

The formulation combines:

Frankincense • Peppermint • Lavender • Copaiba • St John’s Wort • Helichrysum italicum • German Chamomile • Black Spruce • Ginger • Sweet Marjoram • Cedarwood • Clove • Olive Oil

Neuralgia differs fundamentally from ordinary muscular pain.

When a peripheral nerve becomes injured, compressed, inflamed or sensitised, the nerve itself can begin producing abnormal electrical signals.

Pain may then occur without ongoing tissue injury.

Neuralgia Support has therefore been formulated around several interconnected targets:

Peripheral sensory-nerve excitability

TRPM8-mediated analgesic signalling

Voltage-gated ion-channel activity

Peripheral sensitisation

Neuroinflammatory signalling

CB2 receptor activity

Inflammatory cytokines

Oxidative stress

Secondary muscular tension

The objective is not simply to create a warming or cooling sensation.

It is to support the biological environment surrounding an irritated, sensitised or painful peripheral nerve.

WHAT IS NEURALGIA?

Neuralgia describes pain occurring along the distribution of a nerve.

Neuropathic pain can result when the somatosensory nervous system becomes damaged or diseased.

Symptoms are often very different from conventional muscular pain.

They may include:

Burning

Shooting pain

Electric-shock sensations

Stabbing pain

Pins and needles

Tingling

Abnormal sensitivity

Pain from light touch

Cold sensitivity

Numbness accompanied by pain

Two important neurological phenomena are:

ALLODYNIA

Pain produced by a stimulus that would not normally be painful—for example clothing or light touch against the skin.

HYPERALGESIA

An exaggerated pain response to a stimulus that would normally produce some pain.

These symptoms arise because pain-processing pathways can become sensitised.

WHAT HAPPENS TO AN IRRITATED NERVE?

Following nerve injury or inflammation, several processes can occur.

ALTERED ION-CHANNEL EXPRESSION

Sensory neurons depend upon sodium, calcium, potassium and TRP ion channels to generate electrical signals.

Changes in these channels can increase spontaneous nerve firing.

PERIPHERAL SENSITISATION

Nociceptors become more responsive to stimuli.

NEUROINFLAMMATION

Immune cells, Schwann cells and other cells surrounding the nerve can release inflammatory mediators.

These can include:

TNF-α
IL-1β
IL-6
Prostaglandins
Reactive oxygen species

CENTRAL SENSITISATION

Persistent peripheral nerve signalling can eventually increase excitability within spinal-cord pain-processing pathways.

Neuralgia therefore requires a different formulation strategy from ordinary muscular pain.

PEPPERMINT

Menthol — TRPM8 & Neuropathic Analgesic Signalling

Peppermint provides one of the most mechanistically relevant compounds in the entire formulation:

MENTHOL

Menthol activates:

TRPM8

Transient Receptor Potential Melastatin-8

TRPM8 is expressed on sensory neurons, including neurons within the dorsal-root and trigeminal ganglia.

Activation produces cooling sensation—but its neurological function extends beyond simply feeling cold.

TRPM8 activation has been shown experimentally to reduce:

Mechanical allodynia

Thermal hyperalgesia

Sensitised pain signalling following nerve injury

Menthol additionally interacts with:

Voltage-gated sodium channels

Calcium influx

TRPA1 at higher concentrations

and downstream analgesic signalling systems.

Voltage-gated sodium channels are particularly important because they generate and propagate the electrical impulses travelling along peripheral nerves.

Modulation of these channels provides an additional mechanism through which menthol may reduce abnormal nociceptive signalling.

PRINCIPAL ACTIVE COMPONENT

Menthol

SECONDARY COMPONENTS

Menthone • Menthyl Acetate • 1,8-Cineole

PRIMARY PHARMACOLOGICAL RELEVANCE

TRPM8 activation • Peripheral analgesic signalling • Sodium-channel modulation • Mechanical-allodynia support • Thermal-hyperalgesia support

Peppermint therefore forms the principal sensory nerve-modulation component of Neuralgia Support.

COPAIBA

β-Caryophyllene — CB2 Receptor & Neuroinflammatory Regulation

Copaiba commonly contains substantial concentrations of:

β-CARYOPHYLLENE

β-Caryophyllene is particularly interesting in neuropathic pain because it acts as a selective agonist of:

CANNABINOID CB2 RECEPTORS

CB2 receptors are involved in immune-cell signalling and inflammatory regulation without producing the psychotropic effects associated with CB1 activation.

β-Caryophyllene has demonstrated experimental activity relevant to:

Neuropathic pain

Neuroinflammation

Oxidative stress

Microglial activation

TNF-α

IL-1β

IL-6

NF-κB-associated inflammatory signalling

The mechanism can therefore be represented as:

β-CARYOPHYLLENE

↓

CB2 RECEPTOR ACTIVATION

↓

IMMUNE / INFLAMMATORY MODULATION

↓

REDUCED NEUROINFLAMMATORY SIGNALLING

↓

SUPPORT FOR SENSITISED NERVES

PRINCIPAL ACTIVE COMPONENT

β-Caryophyllene

PRIMARY PHARMACOLOGICAL RELEVANCE

CB2 agonism • Neuroinflammatory regulation • Analgesic mechanisms • Cytokine modulation • Neuroprotective support

Copaiba therefore provides one of the strongest mechanistically defined neuroinflammatory components of the formula.

ST JOHN’S WORT

Hyperforin, Hypericin & Neurological Phytochemistry

St John’s Wort — Hypericum perforatum — has a long history of topical use for painful and irritated nerves.

Whole-plant preparations contain biologically active compounds including:

HYPERFORIN

HYPERICIN / PSEUDOHYPERICIN

FLAVONOIDS

depending upon the extract and preparation.

Hyperforin is a particularly pharmacologically active constituent with effects involving neuronal signalling and several neurotransmitter systems.

Experimental studies of Hypericum preparations have investigated:

Neuropathic pain

Hyperalgesia

Nerve-injury pain

Inflammatory pain

PRIMARY PHARMACOLOGICAL RELEVANCE

Traditional nerve-pain support • Neuroactive phytochemistry • Inflammatory modulation

For medicinal standardisation, the exact St John’s Wort preparation should be documented.

LAVENDER

Linalool & Linalyl Acetate — Neuronal Excitability

Lavender contains:

LINALOOL

LINALYL ACETATE

These compounds demonstrate pharmacological effects involving:

Glutamatergic signalling

NMDA-associated pathways

Voltage-dependent calcium channels

Voltage-dependent sodium channels

Neuronal excitability

This is particularly relevant in neuralgia because abnormal nerve excitability is central to neuropathic pain.

Lavender therefore complements Menthol through a different neurological mechanism.

PRINCIPAL ACTIVE COMPONENTS

Linalool • Linalyl Acetate

PRIMARY PHARMACOLOGICAL RELEVANCE

Neuronal-excitability regulation • Ion-channel modulation • Sensory regulation • Inflammatory support

GERMAN CHAMOMILE

Chamazulene & α-Bisabolol — Inflammatory Pain Support

German Chamomile — Matricaria recutita — differs chemically from Roman Chamomile.

Its essential oil contains compounds including:

CHAMAZULENE

α-BISABOLOL

BISABOLOL OXIDES

depending upon source.

These compounds demonstrate significant experimental anti-inflammatory activity.

Chamazulene has been investigated in relation to inflammatory pathways including:

5-LIPOXYGENASE — 5-LOX

which participates in leukotriene synthesis.

α-Bisabolol also demonstrates:

Anti-inflammatory

Analgesic

Antioxidant

pharmacology experimentally.

PRINCIPAL ACTIVE COMPONENTS

Chamazulene • α-Bisabolol • Bisabolol Oxides

PRIMARY PHARMACOLOGICAL RELEVANCE

Inflammatory mediator regulation • Antioxidant support • Pain-pathway support

German Chamomile therefore supports the inflammatory environment surrounding sensitised nerves.

HELICHRYSUM ITALICUM

Neryl Acetate & Sesquiterpene Tissue Support

Helichrysum italicum can contain:

NERYL ACETATE

γ-CURCUMENE

α-PINENE

SELINENES

and related compounds depending upon chemotype.

Its experimental pharmacology includes:

Anti-inflammatory activity

Antioxidant activity

Tissue-protective effects

Within Neuralgia Support, Helichrysum is best positioned as part of the tissue-recovery and inflammatory-support complex surrounding the affected nerve.

PRINCIPAL ACTIVE FRACTION

Neryl Acetate • γ-Curcumene • Pinene and sesquiterpene fractions

PRIMARY PHARMACOLOGICAL RELEVANCE

Inflammatory regulation • Antioxidant support • Tissue recovery

CLOVE

Eugenol — Nociceptive & Ion-Channel Pharmacology

Clove provides:

EUGENOL

one of the more pharmacologically potent phenolic compounds in the formulation.

Eugenol has demonstrated:

Analgesic

Local anaesthetic-like

Anti-inflammatory

Antioxidant

activity.

Its analgesic effects involve several neuronal mechanisms, including effects on:

Voltage-gated sodium channels

TRP channels

Nociceptive nerve signalling

Sodium-channel inhibition is especially relevant because neuropathic pain frequently involves abnormal electrical activity within damaged sensory nerves.

PRINCIPAL ACTIVE COMPONENT

Eugenol

PRIMARY PHARMACOLOGICAL RELEVANCE

Nociceptive signalling modulation • Sodium-channel activity • Local analgesic mechanisms • Inflammatory regulation

Clove therefore complements Menthol and Lavender within the formula’s ion-channel and peripheral nerve component.

FRANKINCENSE

Terpene-Mediated Inflammatory & Neurological Support

Frankincense essential oil contains species-dependent concentrations of:

α-Pinene

α-Thujene

Limonene

Sabinene

and other terpenes.

These compounds demonstrate experimental inflammatory and neuroactive effects.

Frankincense contributes primarily to the inflammatory environment surrounding painful tissues and nerves.

It is important medicinally to distinguish Frankincense essential oil from Boswellia resin extracts containing boswellic acids, because boswellic acids are not major volatile components of conventional distilled Frankincense oil.

PRINCIPAL ACTIVE FRACTION

α-Pinene and related volatile Boswellia terpenes

PRIMARY PHARMACOLOGICAL RELEVANCE

Inflammatory regulation • Neurological support • Tissue comfort

GINGER

Zingiberene-Rich Inflammatory Support

Ginger essential oil commonly contains:

α-ZINGIBERENE

β-SESQUIPHELLANDRENE

β-BISABOLENE

and related volatile compounds.

These differ from gingerol-rich extracts.

The volatile fraction nevertheless demonstrates experimental antioxidant and inflammatory activity.

Within Neuralgia Support, Ginger contributes primarily to:

Inflammatory regulation

Physical discomfort support

Circulatory and tissue support

PRINCIPAL ACTIVE COMPONENTS

α-Zingiberene • β-Sesquiphellandrene • β-Bisabolene

SWEET MARJORAM

Terpinen-4-ol & Neuromuscular Regulation

Sweet Marjoram — Origanum majorana — commonly contains:

Terpinen-4-ol

Sabinene hydrates

γ-Terpinene

α-Terpinene

depending upon chemotype.

Marjoram is particularly useful when nerve pain is accompanied by protective muscular spasm and tension.

Persistent neuralgia frequently causes surrounding muscles to tighten.

That secondary muscular tension can then create additional mechanical stress around the painful region.

PRIMARY PHARMACOLOGICAL RELEVANCE

Neuromuscular relaxation • Antispasmodic support • Secondary muscular-pain support

BLACK SPRUCE

Bornyl Acetate & Monoterpene Support

Black Spruce — Picea mariana — commonly contains:

BORNYL ACETATE

alongside:

α-Pinene

β-Pinene

Camphene

and related monoterpenes.

It contributes principally to:

Musculoskeletal comfort

Inflammatory support

Physical recovery

rather than acting as the primary neuropathic-pain component.

CEDARWOOD

Himachalenes & Sesquiterpene-Rich Support

If the Cedarwood used is Cedrus atlantica, its chemistry commonly contains:

β-HIMACHALENE

α-HIMACHALENE

γ-HIMACHALENE

ATLANTONES

and related sesquiterpenes.

Cedarwood therefore provides a heavier sesquiterpene fraction complementing the rapidly acting menthol and linalool components.

PRIMARY PHARMACOLOGICAL RELEVANCE

Inflammatory support • CNS support • Sensory regulation

THE MULTI-TARGET MECHANISM OF NEURALGIA SUPPORT

The formulation is built around four major components of neuropathic pain.

1. ABNORMAL SENSORY NERVE SIGNALLING

PEPPERMINT

Menthol → TRPM8

CLOVE

Eugenol → ion-channel/nociceptive signalling

LAVENDER

Linalool → neuronal-excitability and ion-channel regulation

This forms the principal:

PERIPHERAL NERVE-SIGNALLING COMPLEX

The target is:

SENSITISED NERVE

↓

ABNORMAL ELECTRICAL ACTIVITY

↓

BURNING / SHOOTING / ELECTRIC PAIN

↓

MENTHOL + EUGENOL + LINALOOL

↓

SENSORY-SIGNAL MODULATION

2. NEUROINFLAMMATION

COPAIBA

β-Caryophyllene → CB2

GERMAN CHAMOMILE

Chamazulene + Bisabolol

FRANKINCENSE

Terpene-mediated inflammatory regulation

HELICHRYSUM

Neryl Acetate + Sesquiterpenes

provide overlapping support for inflammatory signalling surrounding sensitised neural tissues.

The pathways of interest include:

NF-κB

TNF-α

IL-1β

IL-6

5-LOX-associated inflammatory pathways

Oxidative stress

3. NERVE & TISSUE RECOVERY ENVIRONMENT

St John’s Wort

Helichrysum

Copaiba

Frankincense

Ginger

provide complementary phytochemistry relevant to the biological environment surrounding injured or irritated peripheral nerves.

The objective is to support the tissue environment rather than claiming to regenerate severed nerves.

4. SECONDARY MUSCULAR TENSION

Sweet Marjoram

Lavender

Black Spruce

Ginger

Copaiba

address the muscular guarding that frequently develops around chronic painful regions.

This matters because neuropathic pain can produce a cycle:

NERVE PAIN

↓

PROTECTIVE MUSCLE TENSION

↓

LOCAL MECHANICAL STRESS

↓

GREATER DISCOMFORT

↓

MORE MUSCULAR GUARDING

Supporting the muscular component can therefore complement direct sensory-nerve support.

THE NEURALGIA PAIN CYCLE

Neuralgia can be represented physiologically as:

NERVE INJURY / COMPRESSION / IRRITATION

↓

ION-CHANNEL & MEMBRANE CHANGES

↓

ABNORMAL NERVE FIRING

↓

PERIPHERAL SENSITISATION

↓

NEUROINFLAMMATORY MEDIATORS

↓

LOWERED PAIN THRESHOLD

↓

ALLODYNIA / HYPERALGESIA

↓

PERSISTENT NEUROPATHIC PAIN

Neuralgia Support has been formulated to address several points within this cycle simultaneously.

RELEVANT TYPES OF NERVE-ASSOCIATED DISCOMFORT

The biological mechanisms addressed by Neuralgia Support may be relevant as complementary support for:

Burning nerve pain

Shooting or electric-shock sensations

Tingling and painful pins-and-needles sensations

Localized neuropathic pain

Peripheral nerve irritation

Painful hypersensitivity to touch

Post-injury nerve sensitivity

Nerve-associated muscular guarding

Sciatic-type nerve discomfort

Post-herpetic nerve discomfort

Peripheral neuropathic discomfort

The underlying cause should be medically assessed when symptoms are persistent, progressive, severe or unexplained.

DIRECTIONS FOR TOPICAL USE

Apply a small amount to intact skin over or surrounding the affected area and massage gently.

Do not aggressively massage directly over a severely painful or hypersensitive nerve.

For touch-sensitive areas, a thin gentle application may be better tolerated.

Avoid:

Eyes
Face
Mucous membranes
Open wounds
Broken skin
Severely inflamed skin

Wash hands after application.

Patch test before first use.

Peppermint produces cooling and Clove may produce warming or irritation in sensitive skin.

Discontinue if significant burning, redness or worsening nerve pain occurs.

IMPORTANT MEDICAL INFORMATION

Neuralgia is a description of nerve-associated pain, not necessarily the underlying diagnosis.

Persistent neuropathic pain can result from conditions including:

Nerve compression

Diabetes

Shingles

Spinal disorders

Vitamin deficiencies

Medication or chemotherapy-associated neuropathy

Traumatic nerve injury

Autoimmune or inflammatory disorders

and numerous other neurological conditions.

New or progressive numbness, weakness, loss of coordination or muscle wasting requires medical assessment.

SEEK URGENT MEDICAL ATTENTION

for nerve pain accompanied by:

Sudden weakness or paralysis

Loss of bladder or bowel control

Numbness around the groin/saddle area

New facial weakness

Difficulty speaking

Sudden severe neurological symptoms

or rapidly progressive loss of sensation.

Neuralgia Support is intended as complementary topical support and does not replace investigation or treatment of the underlying neurological disorder.

NEURALGIA SUPPORT

Advanced Neuropathic Pain & Nerve-Calming Support

Neuralgia Support has been constructed around the biology of sensitised peripheral nerves, rather than treating nerve pain as ordinary muscular discomfort.

Menthol from Peppermint activates TRPM8 receptors on sensory neurons and influences voltage-gated ion channels, providing a defined mechanism relevant to allodynia, hyperalgesia and neuropathic pain.

β-Caryophyllene from Copaiba activates CB2 receptors, providing a complementary mechanism involving neuroinflammation, immune signalling and neuropathic-pain pathways.

Linalool from Lavender supports regulation of neuronal excitability and ion-channel signalling.

Eugenol from Clove contributes analgesic, local anaesthetic-like and sodium-channel-related activity.

German Chamomile contributes chamazulene and α-bisabolol to inflammatory-pain regulation.

Helichrysum, Frankincense, Ginger and St John’s Wort preparations support the inflammatory and tissue environment surrounding irritated nerves.

Sweet Marjoram, Black Spruce and Lavender address the secondary muscular tension frequently accompanying chronic neuralgia.

The resulting strategy is:

IRRITATED / DAMAGED NERVE

↓

ABNORMAL ELECTRICAL FIRING

Menthol • Eugenol • Linalool
↓

SENSORY-NERVE MODULATION

PERIPHERAL SENSITISATION

Menthol → TRPM8
↓

ALLODYNIA / HYPERALGESIA SUPPORT

NEUROINFLAMMATION

β-Caryophyllene → CB2
Chamazulene • Bisabolol • Frankincense Terpenes
↓

INFLAMMATORY-SIGNAL REGULATION

OXIDATIVE & TISSUE STRESS

Helichrysum • Copaiba • Ginger • Frankincense
↓

NERVE-ENVIRONMENT SUPPORT

SECONDARY MUSCULAR GUARDING

Marjoram • Lavender • Black Spruce • Ginger
↓

NEUROMUSCULAR COMFORT

NEURALGIA SUPPORT

Calm abnormal sensory signalling.
Target peripheral nerve hypersensitivity.
Support TRPM8-mediated analgesic pathways.
Regulate neuroinflammatory signalling.
Support the tissue environment surrounding irritated nerves.
Reduce secondary muscular tension.